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Cluster profiles are named according to filesystem configuration and version.
Select the file which corresponds to your current version of MATLAB and your filesystem configuration.
You will be able to use any toolboxes that you have a license for by submitting batch jobs from your MATLAB client.
The batch jobs you submit from your MATLAB client through the PCT will be able to utilize functions such as "parfor" and "spmd" to run your code in parallel, in addition to being able to run normal MATLAB code.
On Demand or VNC is needed to use this (the MATLAB PCT is GUI only at this time), but it will allow you to debug your parallel jobs using various tools in real time.