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Glucosamine sulfate used in dietary supplements does not always come from natural sources. There are different forms of glucosamine including glucosamine sulfate, glucosamine hydrochloride, and N-acetyl-glucosamine. Graeser AC, Giller K, Wiegand H, Barella L, Boesch Saadatmandi C, Rimbach G.
This is one reason why researchers believe that glucosamine sulfate might work better than other forms of glucosamine such as glucosamine hydrochloride or N-acetyl glucosamine. Glucosamine sulfate is LIKELY SAFE when used appropriately by mouth in adults. A randomized, double blind, placebo controlled trial of a topical cream containing glucosamine sulfate, chondroitin sulfate, and camphor for osteoarthritis of the knee.
Glucosamine sulfate is POSSIBLY SAFE when injected into the muscle as a shot twice weekly for up to 6 weeks or when applied to the skin in combination with chondroitin sulfate, shark cartilage, and camphor for up to 8 weeks.
So far, researchers have found no proof that combining the additional ingredients with glucosamine adds any benefit.
Some glucosamine sulfate products are not labeled accurately. Fransen M, Agaliotis M, Nairn L, Votrubec M, Bridgett L, Su S, Jan S, March L, Edmonds J, Norton R, Woodward M, Day R; LEGS study collaborative group.
These creams usually contain camphor and other ingredients in addition to glucosamine. Does glucosamine increase serum lipid levels and blood pressure? Therapeutic activity of oral glucosamine sulfate in osteoarthrosis: a placebo-controlled double-blind investigation.